What's the Line

Injury Report

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Sep 21, 2025

NFL Lines for September 21, 2025

Green Bay Packers

Cleveland Browns

1:00 PM ET

Cleveland, OH, Huntington Bank Field

Select the favorite:

Green Bay Packers

Cleveland Browns

Spread (points favored by):

Indianapolis Colts

Tennessee Titans

1:00 PM ET

Nashville, TN, Nissan Stadium

Select the favorite:

Indianapolis Colts

Tennessee Titans

Spread (points favored by):

Cincinnati Bengals

Minnesota Vikings

1:00 PM ET

Minneapolis, MN, U.S. Bank Stadium

Select the favorite:

Cincinnati Bengals

Minnesota Vikings

Spread (points favored by):

Pittsburgh Steelers

New England Patriots

1:00 PM ET

Foxborough, MA, Gillette Stadium

Select the favorite:

Pittsburgh Steelers

New England Patriots

Spread (points favored by):

Los Angeles Rams

Philadelphia Eagles

1:00 PM ET

Philadelphia, PA, Lincoln Financial Field

Select the favorite:

Los Angeles Rams

Philadelphia Eagles

Spread (points favored by):

New York Jets

Tampa Bay Buccaneers

1:00 PM ET

Tampa, FL, Raymond James Stadium

Select the favorite:

New York Jets

Tampa Bay Buccaneers

Spread (points favored by):

Las Vegas Raiders

Washington Commanders

1:00 PM ET

Landover, MD, Northwest Stadium

Select the favorite:

Las Vegas Raiders

Washington Commanders

Spread (points favored by):

Atlanta Falcons

Carolina Panthers

1:00 PM ET

Charlotte, NC, Bank of America Stadium

Select the favorite:

Atlanta Falcons

Carolina Panthers

Spread (points favored by):

Houston Texans

Jacksonville Jaguars

1:00 PM ET

Jacksonville, FL, EverBank Stadium

Select the favorite:

Houston Texans

Jacksonville Jaguars

Spread (points favored by):

Denver Broncos

Los Angeles Chargers

4:05 PM ET

Inglewood, CA, SoFi Stadium

Select the favorite:

Denver Broncos

Los Angeles Chargers

Spread (points favored by):

New Orleans Saints

Seattle Seahawks

4:05 PM ET

Seattle, WA, Lumen Field

Select the favorite:

New Orleans Saints

Seattle Seahawks

Spread (points favored by):

Dallas Cowboys

Chicago Bears

4:25 PM ET

Chicago, IL, Soldier Field

Select the favorite:

Dallas Cowboys

Chicago Bears

Spread (points favored by):

Arizona Cardinals

San Francisco 49ers

4:25 PM ET

Santa Clara, CA, Levi's Stadium

Select the favorite:

Arizona Cardinals

San Francisco 49ers

Spread (points favored by):

Kansas City Chiefs

New York Giants

8:20 PM ET

East Rutherford, NJ, MetLife Stadium

Select the favorite:

Kansas City Chiefs

New York Giants

Spread (points favored by):

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Green Bay Packers

Cleveland Browns

1:00 PM ET

Cleveland, OH, Huntington Bank Field

Game Total:

Indianapolis Colts

Tennessee Titans

1:00 PM ET

Nashville, TN, Nissan Stadium

Game Total:

Cincinnati Bengals

Minnesota Vikings

1:00 PM ET

Minneapolis, MN, U.S. Bank Stadium

Game Total:

Pittsburgh Steelers

New England Patriots

1:00 PM ET

Foxborough, MA, Gillette Stadium

Game Total:

Los Angeles Rams

Philadelphia Eagles

1:00 PM ET

Philadelphia, PA, Lincoln Financial Field

Game Total:

New York Jets

Tampa Bay Buccaneers

1:00 PM ET

Tampa, FL, Raymond James Stadium

Game Total:

Las Vegas Raiders

Washington Commanders

1:00 PM ET

Landover, MD, Northwest Stadium

Game Total:

Atlanta Falcons

Carolina Panthers

1:00 PM ET

Charlotte, NC, Bank of America Stadium

Game Total:

Houston Texans

Jacksonville Jaguars

1:00 PM ET

Jacksonville, FL, EverBank Stadium

Game Total:

Denver Broncos

Los Angeles Chargers

4:05 PM ET

Inglewood, CA, SoFi Stadium

Game Total:

New Orleans Saints

Seattle Seahawks

4:05 PM ET

Seattle, WA, Lumen Field

Game Total:

Dallas Cowboys

Chicago Bears

4:25 PM ET

Chicago, IL, Soldier Field

Game Total:

Arizona Cardinals

San Francisco 49ers

4:25 PM ET

Santa Clara, CA, Levi's Stadium

Game Total:

Kansas City Chiefs

New York Giants

8:20 PM ET

East Rutherford, NJ, MetLife Stadium

Game Total:

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Green Bay Packers

Cleveland Browns

1:00 PM ET

Cleveland, OH, Huntington Bank Field

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Green Bay Packers at:

Cleveland Browns at:

Implied other team: --

Indianapolis Colts

Tennessee Titans

1:00 PM ET

Nashville, TN, Nissan Stadium

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Indianapolis Colts at:

Tennessee Titans at:

Implied other team: --

Cincinnati Bengals

Minnesota Vikings

1:00 PM ET

Minneapolis, MN, U.S. Bank Stadium

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Cincinnati Bengals at:

Minnesota Vikings at:

Implied other team: --

Pittsburgh Steelers

New England Patriots

1:00 PM ET

Foxborough, MA, Gillette Stadium

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Pittsburgh Steelers at:

New England Patriots at:

Implied other team: --

Los Angeles Rams

Philadelphia Eagles

1:00 PM ET

Philadelphia, PA, Lincoln Financial Field

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Los Angeles Rams at:

Philadelphia Eagles at:

Implied other team: --

New York Jets

Tampa Bay Buccaneers

1:00 PM ET

Tampa, FL, Raymond James Stadium

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

New York Jets at:

Tampa Bay Buccaneers at:

Implied other team: --

Las Vegas Raiders

Washington Commanders

1:00 PM ET

Landover, MD, Northwest Stadium

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Las Vegas Raiders at:

Washington Commanders at:

Implied other team: --

Atlanta Falcons

Carolina Panthers

1:00 PM ET

Charlotte, NC, Bank of America Stadium

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Atlanta Falcons at:

Carolina Panthers at:

Implied other team: --

Houston Texans

Jacksonville Jaguars

1:00 PM ET

Jacksonville, FL, EverBank Stadium

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Houston Texans at:

Jacksonville Jaguars at:

Implied other team: --

Denver Broncos

Los Angeles Chargers

4:05 PM ET

Inglewood, CA, SoFi Stadium

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Denver Broncos at:

Los Angeles Chargers at:

Implied other team: --

New Orleans Saints

Seattle Seahawks

4:05 PM ET

Seattle, WA, Lumen Field

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

New Orleans Saints at:

Seattle Seahawks at:

Implied other team: --

Dallas Cowboys

Chicago Bears

4:25 PM ET

Chicago, IL, Soldier Field

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Dallas Cowboys at:

Chicago Bears at:

Implied other team: --

Arizona Cardinals

San Francisco 49ers

4:25 PM ET

Santa Clara, CA, Levi's Stadium

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Arizona Cardinals at:

San Francisco 49ers at:

Implied other team: --

Kansas City Chiefs

New York Giants

8:20 PM ET

East Rutherford, NJ, MetLife Stadium

Pick a team and predict their moneyline:

💡 Negative odds = favorite (bet more to win less) | Positive odds = underdog (bet less to win more)

Kansas City Chiefs at:

New York Giants at:

Implied other team: --

The games for September 21, 2025 have already started or completed.

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